Publications

2024

  • Clarke, D. N., Formery, L., & Lowe, C. J. See-Star: a versatile hydrogel-based protocol for clearing large, opaque and calcified marine invertebrates. bioRxiv, 2024-03. DOI:doi.org/10.1101/2024.03.16.585344
  • Vyas, P., Brannon, C. M., Formery, L., Lowe, C., & Prakash, M. Algorithmic construction of topologically complex biomineral lattices via cellular syncytia. bioRxiv, 2024-02. DOI:doi.org/10.1101/2024.02.20.580924 

2023

  • Formery, L., Peluso, P., Kohnle, I., Malnick, J., Thompson, J. R., Pitel, M., Uhlinger, K. R., Rokhsar, D. S., Rank, D. R., Lowe, C. J. Molecular evidence of anteroposterior patterning in adult echinoderms. Nature. DOI:doi.org/10.1038/s41586-023-06669-2
  • Andrade López, J. M., Pani, A. M., Wu, M., Gerhart, J., & Lowe, C. J. Molecular characterization of nervous system organization in the hemichordate acorn worm Saccoglossus kowalevskii. Plos Biology, 21(9), e3002242. DOI:doi.org/10.1371/journal.pbio.3002242
  • Formery, L., Lowe C.J. Integrating Complex Life Cycles in Comparative Developmental Biology. Annual Review of Genetics, 57. DOI:doi.org/10.1146/annurev-genet-071719-020641

2022

  • Bump, P., Khariton, M., Stubbert, C., Moyen, N. E., Yan, J., Wang, B., & Lowe, C. J. Comparisons of cell proliferation and cell death from tornaria larva to juvenile worm in the hemichordate Schizocardium californicum. EvoDevo, 13(1), 1-20. DOI:10.1186/s13227-022-00198-1
  • Gray, J., Fritzenwanker, J. H., Cunningham, D. D., & Lowe, C. J. Saccoglossus kowalevskii: Evo-devo insights from the mud. Current Topics in Developmental Biology. DOI:10.1016/bs.ctdb.2022.01.004

2021

  • Gąsiorowski, L., Andrikou, C., Janssen, R., Bump, P., Budd, G. E., Lowe, C. J., & Hejnol, A. Molecular evidence for a single origin of ultrafiltration-based excretory organs. Current Biology, 31, 3629-3638.e2. DOI:10.1016/j.cub.2021.05.057
  • Lowe, C. J. Molecular insights into deuterostome evolution from hemichordate developmental biology. In Evolutionary Developmental Biology, 141, 75. Ed. Gilbet, S. F. Elsevier
  • Formery, L., Orange, F., Formery, A., Yaguchi, S., Lowe, C. J., Schubert, M., & Croce, J. C. Neural anatomy of echinoid early juveniles and comparison of nervous system organization in echinoderms. Journal of Comparative Neurology, 529(6), 1135-1156. DOI:10.1002/cne.25012

2019

  • Fritzenwanker J.H., Uhlinger K.R., Gerhart J., Silva E., Lowe, C.J. Untangling posterior growth and segmentation by analyzing mechanisms of axis elongation in hemichordates. Proceedings of the National Academy of Sciences, 116(17), 8403-8408. DOI:10.1073/pnas.1817496116
  • Clarke, D.N., Lowe, C.J., Nelson, W.J. The cadherin-catenin complex is necessary for cell adhesion and embryogenesis in Nematostella vectensis. Developmental Biology, 447(2), 170-181. DOI:10.1016/j.ydbio.2019.01.007

2018

  • Minor, P., Clarke, D.N., Andrade Lopez, J., Fritzenwanker, J.H., Grey, J., Lowe, C.J. I-SceIMeganuclease-mediated transgenesis in the acorn worm, Saccoglossus kowalevskii. Developmental Biology, 445(1), 8-15. DOI:10.1016/j.ydbio.2018.10.022
  • Lowe, C. J. The Backbone begins: a spine-tingling story. Review of Across the Bridge. Understanding the Origins of Vertebrates. Nature, 559(7712), 31-31. DOI:10.1038/d41586-018-05603-1
  • Gonzalez, P., Jiang, J. Z., & Lowe, C. J. The development and metamorphosis of the indirect developing acorn worm Schizocardium californicum (Enteropneusta: Spengelidae). Frontiers in zoology, 15(1), 1-24. DOI:10.1186/s12983-018-0270-0
  • Darras, S., Fritzenwanker, J. H., Uhlinger, K. R., Farrelly, E., Pani, A. M.,  Hurley, I. A., Norris, R. P., Osovitz, M., Terasaki, M., Wu, M., Aronowicz, J., Kirschner, M., Gerhart, J. C., Lowe, C. J., Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development. PLoS biology, 16(1), e2003698. DOI:10.1371/journal.pbio.2003698

2017

  • Gonzalez P, Uhlinger KR, Lowe CJ. The adult body plan of indirect developing hemichordates develops by adding a hox-patterned trunk to an anterior larval territory. Current biology, 27(1), 87-95. DOI:10.1016/j.cub.2016.10.047

2016

  • Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nature genetics (May 2016). PMID: 27064252
  • Clarke, D.N., Miller, P.W., Lowe, C.J., Weis, W.I. and Nelson, W.J., 2016. Characterization of the cadherin-catenin complex of the sea anemone Nematostella vectensis and implications for the evolution of metazoan cell-cell adhesion. Molecular biology and evolution (Apr 2016). PMID: 27189570

2015

  • Lowe, C.J., Terasaki, M., Wu, M., Freeman Jr, R.M., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander, E., Gruber, C. and Smith, M. Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution. PLoS Biol (Dec 2015). PMID: 26714185
  • Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM Jr, Sasaki A, Hikosaka-Katayama T, Sato A, Fujie M, Baughman KW, Levine J, Gonzalez P, Cameron C, Fritzenwanker JH, Pani AM, Goto H, Kanda M, Arakaki N, Yamasaki S, Qu J, Cree A, Ding Y, Dinh HH, Dugan S, Holder M, Jhangiani SN, Kovar CL, Lee SL, Lewis LR, Morton D, Nazareth LV, Okwuonu G, Santibanez J, Chen R, Richards S, Muzny DM, Gillis A, Peshkin L, Wu M, Humphreys T, Su YH, Putnam NH, Schmutz J, Fujiyama A, Yu JK, Tagawa K, Worley KC, Gibbs RA, Kirschner MW, Lowe CJ, Satoh N, Rokhsar DS, Gerhart J. Hemichordate genomes and deuterostome origins. Nature (Nov 2015). PMID: 26580012
  • A Hejnol, CJ Lowe. Embracing the comparative approach: how robust phylogenies and broader developmental sampling impacts the understanding of nervous system evolution. Phil. Trans. R. Soc. B (2015). PMID: 26554039
  • D’Aniello S, Delroisse J, Valero-Gracia A, Lowe EK, Byrne M, Cannon JT, Halanych KM, Elphick MR, Mallefet J, Kaul-Strehlow S, Lowe CJ, Flammang P, Ullrich-Lüter E, Wanninger A, Arnone MI. Opsin evolution in the Ambulacraria. Marine genomics (Nov 2015). PMID: 26472700
  • Hodin J., Ferner M.C., Ng G, Lowe C.J., Gaylord B. Rethinking competence in marine life cycles: ontogenetic changes in the settlement response of sand dollar larvae exposed to turbulence. Royal Society open science (Jun 2015). PMID: 26543587
  • Lowe C.J., Clarke, D.N., Medeiros, D.M., Rokhsar, D.S., Gerhart, J. The deuterostome context of chordate origins. Nature (Apr 2015). PMID: 25903627
  • Elphick M.R., Semmens D.C., Blowes L.M., Levine J, Lowe C.J., Arnone M.I., Clark M.S. Reconstructing SALMFamide Neuropeptide Precursor Evolution in the Phylum Echinodermata: Ophiuroid and Crinoid Sequence Data Provide New Insights. Frontiers in Endocrinology (Feb 2015). PMCID: PMC4313774

2014

  • Hejnol, A., and Lowe C.J. Animal evolution: stiff or squishy notochord origins? Cure Biol (Dec 2014). PMID: 25465334
  • Fritzenwanker JH, Gerhart J, Freeman RM Jr, Lowe CJ. The Fox/Forkhead transcription factor family of the hemichordate Saccoglossus kowalevskii. Evodevo. May 7;5:17. PMID: 24987514
  • Telford MJ, Lowe CJ, Cameron CB, Ortega-Martinez O, Aronowicz J, Oliveri P, Copley RR. Phylogenomic analysis of echinoderm class relationships supports Asterozoa. Proc Biol Sci. 2014 Jul 7;281(1786). PMID: 24850925

2013

  • Lowe, C.J. What led to Metazoa’s Big Bang. Science 340 (6137): 1170-1171. DOI: 10.1126/science.1237431
  • Green, S. G., Norris, R., Teresaki, M., Lowe, C. J. FGF signaling induces mesoderm in the hemichordate S.kowalevskii. Development 140. PMID: 23344709
  • Miller, P.W., Clarke, D.N., Weis, W.I., Lowe C.J., Nelson, W.J. The Origin of Epithelial Cell–Cell Adhesion Mechanisms. Current Topics in Membranes, 72, 269-313. PMID: 24210433

2012

  • Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, Rokhsar D, Satoh N, Gerhart J. Identical genomic organization of two hemichordate hox clusters. Curr Biol. 2012 Nov 6;22(21):2053-8. PMID:23063438
  • Röttinger E, Lowe CJ. Evolutionary crossroads in developmental biology:hemichordates. Development. 2012 Jul;139(14):2463-75. PMID: 22736243
  • Pani A.M , Mullarkey E.E. Aronowicz J, Assimacopoulos S., Grove E. A, & Lowe C. J. Ancient deuterostome origins of vertebrate brain signalling centres. Nature. 2012 Mar 14;483(7389) 289-94. PMID: 22422262

2011

  • Gillis JA, Fritzenwanker JH, Lowe CJ. A stem-deuterostome origin of the vertebrate pharyngeal transcriptional network. Proc Biol Sci. 2011 Jun 15. PMID: 21676974
  • Lowe CJ, Pani AM. Animal evolution: a soap opera of unremarkable worms. Curr Biol. 2011 Feb 22;21(4):R151-3. PMID: 21334293
  • Darras, S., J. Gerhart, et al. Beta-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development. 138(5): 959-70. PMID: 21303849
  • Tiago Sobreira, Ferdinand Marlétaz, Marcos Simões-Costa, Deborah Schechtman, Alexandre Pereira, Frédéric Brunet, Sarah Sweeney, Ariel Pani, Jochanan Aronowicz, Chris Lowe , Brad Davidson, Vincent Laudet, Marianne Bronner-Fraser, Paulo de Oliveira, Michael Schubert, Jose Xavier-Neto. Structural shifts of ALDH enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):226-31. Epub 2010 Dec 17. PMID: 21169504

2010

  • Lemons D, Fritzenwanker JH, Gerhart J, Lowe CJ, McGinnis W. Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution. Dev Biol. 2010 May 7. PMID: 20435033

2009

  • Gray RS, Bayly RD, Green SA, Agarwala S, Lowe CJ, Wallingford JB. Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution. Dev Dyn. 2009 Aug;238(8):2044-57. PMID: 19618470
  • Nomaksteinsky M, Röttinger E, Dufour HD, Chettouh Z, Lowe CJ, Martindale MQ, Brunet JF.  Centralization of the deuterostome nervous system predates chordates. Curr Biol. 2009 Aug 11;19(15):1264-9. Epub 2009 Jun 25. PMID: 19559615

2008

  • Freeman RM Jr, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange Thomann N, Lowe CJ, Gerhart J, Kirschner M. cDNA Sequences for Transcription Factors and Signaling Proteins of the Hemichordate Saccoglossus kowalevskii: Efficacy of the Expressed Sequence Tag (EST) Approach for Evolutionary and Developmental Studies of a New Organism. Biol Bull. 2008 Jun;214(3):284-302. PMID: 18574105
  • Lowe C. J. Molecular genetic insights into deuterostome evolution from the direct-developing hemichordate Saccoglosus kowalevskii. Phil. Trans. R. Soc. B. 363, 1569-1578. PMID: 18192177

2007

  • Lowe C. J. Origins of the Chordate Central Nervous System: Insights from Hemichordates. In Evolution of Nervous Systems. Ed. Kaas, J. Vol 4 pp 25-35. (Academic Press)

2006

  • Lowe C. J., Terasaki M., Wu, M., Freeman, R.M. Jr., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander E., Gruber, C., Smith, M., Kirschner, M., Gerhart, J. Dorsoventral patterning in hemichordates: insights into early chordate evolution. PLoS Biol. Sep;4(9):e291
  • Aronowicz, J., Lowe, C.J. Hox gene expression in the hemichordate S. kowalevskii and the evolution of deuterostome nervous systems. Integrative and Comparative Biology, 46(6), 890-901. DOI:10.1093/icb/icl045
  • Bourlat SJ, Juliusdottir T, Lowe CJ, Freeman R, Aronowicz J, Kirschner M, Lander ES, Thorndyke M, Nakano H, Kohn AB, Heyland A, Moroz LL, Copley RR, Telford MJ. Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida. Nature. Nov 2:444(7115): 85-8. Epub Oct 18.
  • Marletaz F, Martin E, Perez Y, Papillon D, Caubit X, Lowe CJ, Freeman B, Fasano L, Dossat C, Wincker P, Weissenbach J, Le Parco Y. Chaetognath phylogenomics: a protostome with deuterostome-like development. Curr Biol. 2006 Aug 8;16(15):R577-8

2005

2004

  • Lowe, C.J., Tagawa, K., Kirschner, M., Gerhart, J. Hemichordate embryos: Procurement, culture and basic methods. In Experimental Analysis of the development of sea urchins and other non-vertebrate deuterostomes. Eds Charles Ettensohn, Gregory Wray, and Gary Wessel. Methods in Cell Biology, 74. Elsevier

2003

  • Lowe C.J., Wu M., Salic, A., Evans, L., Lander E., Stange-Thomann, N., Gruber, C., Gerhart, J., Kirschner, M. Anteroposterior Patterning in Hemichordates and the Origins of the Chordate Nervous System. Cell, 113, 853-865. DOI:10.1016/S0092-8674(03)00469-0

2002

  • Lowe, C.J., Issel-tarver, L., Wray, G. A. Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae. Evolution and Development, 4(2), 111-123. DOI:10.1046/j.1525-142X.2002.01066.x

2000

  • Lowe, C. J., and Wray, G. A. Rearing larvae of sea urchins and sea stars for developmental studies. In Developmental Biology Protocols. Eds. R. S. Tuan and C.W. Lo. Humana Press
  • Wray, G.A. and Lowe, C.J. Developmental regulatory genes and echinoderm evolution. Systematic Biology, 49(1),  28-51. DOI:10.1080/10635150050207375

1997

  • Lowe, C.J. and Wray, G.A. Radical alterations in the roles of homeobox genes during echinoderm evolution. Nature, 389, 718-721. DOI:10.1038/39580